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Well-differentiated liposarcoma

3 associated genes
4 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
13 signs/symptoms

Well-differentiated liposarcoma

IMAGe syndrome

CDK4	(UniProt - OMIM)		CDKN1C	(UniProt - OMIM)
HMGA2	(UniProt - OMIM)
MDM2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CDK4	(0.65)	CDKN1C

Citations in the biomedical literature:

Well-differentiated liposarcoma		IMAGe syndrome
	Synonym(s): - ALT - Atypical lipoma - Atypical lipomatous tumor - WDLS		Synonym(s): - Intrauterine growth retardation - metaphyseal dysplasia - adrenal hypoplasia congenita - genital anomalies

	Classification (Orphanet): - Rare oncologic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare urogenital disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: adult Type of inheritance: sporadic		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant

	External references: No OMIM references No MeSH references		External references: 1 OMIM reference - No MeSH references

Well-differentiated liposarcoma		IMAGe syndrome
	Very frequent - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma - Subcutaneous nodules / lipomas / tumefaction / swelling Occasional - Functional anomalies of the kidney and the urinary tract - Intestinal transit disorder		Very frequent - Adrenal glands anomalies - Anomalies of bones / skeletal anomalies - Autosomal recessive inheritance - Depressed nasal bridge - Frontal bossing / prominent forehead - Hypospadias / epispadias / bent penis - Hypotonia - Intrauterine growth retardation - Late puberty / hypogonadism / hypogenitalism - Low set ears / posteriorly rotated ears - Megaureter / hydronephrosis / pyeloureteral junction syndrome - Short limbs / micromelia / brachymelia - Undescended / ectopic testes / cryptorchidia / unfixed testes